The 5-HT(1A) Receptor PET Radioligand (11)C-CUMI-101 Has Significant Binding to α(1)-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

Prazosin, a potent and selective α(1)-adrenoceptor antagonist, displaces 25% of (11)C-CUMI-101 ([O-methyl-(11)C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione) binding in monkey cerebellum. We sought to estimate the percentage contamination of (11)C-CUMI-101 b...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Shrestha, Stal S., Liow, Jeih-San, Jenko, Kimberly, Ikawa, Masamichi, Zoghbi, Sami S., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2016
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126696/
https://ncbi.nlm.nih.gov/pubmed/27587705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.174151
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