Cerebellum can serve as a pseudo-reference region in Alzheimer’s disease to detect neuroinflammation measured with PET radioligand binding to translocator protein (TSPO)

Alzheimer’s disease (AD) is associated with increase in brain of the 18 kDa translocator protein (TSPO), which is over-expressed in activated microglia and reactive astrocytes. Measuring the density of TSPO with PET typically requires absolute quantitation with arterial blood sampling, because a ref...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Lyoo, Chul Hyoung, Ikawa, Masamichi, Liow, Jeih-San, Zoghbi, Sami S., Morse, Cheryl, Pike, Victor W., Fujita, Masahiro, Innis, Robert B., Kreisl, William Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839390/
https://ncbi.nlm.nih.gov/pubmed/25766898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.114.146027
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