Metabotropic Glutamate Subtype 5 Receptors Are Quantified in the Human Brain with a Novel Radioligand for PET

We developed a radioligand, 3-fluoro-5-(2-(2-(18)F-(fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ((18)F-SP203), for metabotropic glutamate subtype 5 (mGluR5) receptors that showed both promising (high specific binding) and problematic (defluorination) imaging characteristics in animals. The purpo...

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Detalhes bibliográficos
Main Authors: Brown, Amira K., Kimura, Yasuyuki, Zoghbi, Sami S., Siméon, Fabrice G., Liow, Jeih-San, Kreisl, William C., Taku, Andrew, Fujita, Masahiro, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760157/
https://ncbi.nlm.nih.gov/pubmed/19038998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.056291
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