Radiodefluorination of 3-Fluoro-5-(2-(2-[(18)F](fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile ([(18)F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain

Metabotropic glutamate subtype-5-receptors (mGluR5) are implicated in several neuropsychiatric disorders. Positron emission tomography (PET) with a suitable radioligand may enable monitoring of regional brain mGluR5 density before and during treatments. We have developed a new radioligand, 3-fluoro-...

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Hlavní autoři: Shetty, H. Umesha, Zoghbi, Sami S., Siméon, Fabrice G., Liow, Jeih-San, Brown, Amira K., Kannan, Pavitra, Innis, Robert B., Pike, Victor W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679677/
https://ncbi.nlm.nih.gov/pubmed/18806125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.143347
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