Imaging and Quantitation of Cannabinoid CB(1) Receptors in Human and Monkey Brains Using (18)F-Labeled Inverse Agonist Radioligands

We recently demonstrated that (11)C-MePPEP, a PET ligand for CB(1) receptors, has such high uptake in the human brain that it can be imaged for 210 min and that receptor density can be quantified as distribution volume (V(T)) using the gold standard of compartmental modeling. However, (11)C-MePPEP h...

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Detalhes bibliográficos
Main Authors: Terry, Garth E., Hirvonen, Jussi, Liow, Jeih-San, Zoghbi, Sami S., Gladding, Robert, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Donohue, Sean R., Pike, Victor W., Halldin, Christer, Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997525/
https://ncbi.nlm.nih.gov/pubmed/20008988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.067074
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