Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

[(11)C]MePPEP is a high affinity, CB(1) receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [(11)C]MePPEP to quantify CB(1) receptors in human brain as distribution volume calculated with the “gold standard” method of compartmental modeling an...

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Main Authors: Terry, Garth E., Liow, Jeih-San, Zoghbi, Sami S., Hirvonen, Jussi, Farris, Amanda G., Lerner, Alicja, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Hong, Jinsoo S., Pike, Victor W., Halldin, Christer, Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730982/
https://ncbi.nlm.nih.gov/pubmed/19573609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2009.06.059
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