Comparison of two PET radioligands, [(11)C]FPEB and [(11)C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain

Of the two (18)F-labeled PET ligands currently available to image metabotropic glutamate receptor 5 (mGluR5), [(18)F]FPEB is reportedly superior because [(18)F]SP203 undergoes glutathionlyation, generating [(18)F]-fluoride ion that accumulates in brain and skull. To allow multiple PET studies on the...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Lohith, Talakad G, Tsujikawa, Tetsuya, Siméon, Fabrice G, Veronese, Mattia, Zoghbi, Sami S, Lyoo, Chul Hyoung, Kimura, Yasuyuki, Morse, Cheryl L, Pike, Victor W, Fujita, Masahiro, Innis, Robert B
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531344/
https://ncbi.nlm.nih.gov/pubmed/27629098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16668891
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