Quantification of metabotropic glutamate subtype 5 receptors in brain by an equilibrium method using (18)F-SP203

A new PET ligand, 3-fluoro-5-(2-(2-(18)F-(fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ((18)F-SP203) can quantify metabotropic glutamate subtype 5 receptors (mGluR5) in human brain by a bolus injection and kinetic modeling. As an alternative approach to a bolus injection, binding can simply be me...

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Autors principals: Kimura, Yasuyuki, Siméon, Fabrice G., Zoghbi, Sami S., Zhang, Yi, Hatazawa, Jun, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254783/
https://ncbi.nlm.nih.gov/pubmed/22032949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.10.028
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