A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation

Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous...

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Hlavní autoři: Kreisl, William C, Jenko, Kimberly J, Hines, Christina S, Hyoung Lyoo, Chul, Corona, Winston, Morse, Cheryl L, Zoghbi, Sami S, Hyde, Thomas, Kleinman, Joel E, Pike, Victor W, McMahon, Francis J, Innis, Robert B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597372/
https://ncbi.nlm.nih.gov/pubmed/22968319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.131
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