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Effects of Ketoconazole on the Biodistribution and Metabolism of [(11)C]Loperamide and [(11)C]N-Desmethyl-loperamide in Wild-type and P-gp Knockout Mice
INTRODUCTION: [(11)C]Loperamide and [(11)C]N-desmethyl-loperamide ([(11)C]dLop) have been proposed as radiotracers for imaging brain P-glycoprotein (P-gp) function. A major route of [(11)C]loperamide metabolism is N-demethylation to [(11)C]dLop. We aimed to test whether inhibition of CYP3A4 with ket...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847595/ https://ncbi.nlm.nih.gov/pubmed/20346873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2009.12.010 |
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