Effects of Ketoconazole on the Biodistribution and Metabolism of [(11)C]Loperamide and [(11)C]N-Desmethyl-loperamide in Wild-type and P-gp Knockout Mice

INTRODUCTION: [(11)C]Loperamide and [(11)C]N-desmethyl-loperamide ([(11)C]dLop) have been proposed as radiotracers for imaging brain P-glycoprotein (P-gp) function. A major route of [(11)C]loperamide metabolism is N-demethylation to [(11)C]dLop. We aimed to test whether inhibition of CYP3A4 with ket...

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Main Authors: Seneca, Nicholas, Zoghbi, Sami S., Shetty, H. Umesha, Tuan, Edward, Kannan, Pavitra, Taku, Andrew, Innis, Robert B., Pike, Victor W.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847595/
https://ncbi.nlm.nih.gov/pubmed/20346873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2009.12.010
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