P-Glycoprotein Function at the Blood-Brain Barrier Imaged in Monkey with (11)C-N-Desmethyl-Loperamide

(11)C-Loperamide is an avid substrate for P-glycoprotein (P-gp), but it is rapidly metabolized to (11)C-N-desmethyl-loperamide ((11)C-dLop), which is also a substrate for P-gp and thereby contaminates the radioactive signal in brain. Since further demethylation of (11)C-dLop generates radiometabolit...

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Detalhes bibliográficos
Principais autores: Liow, Jeih-San, Kreisl, William, Zoghbi, Sami S., Lazarova, Neva, Seneca, Nicholas, Gladding, Robert L., Taku, Andrew, Herscovitch, Peter, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652692/
https://ncbi.nlm.nih.gov/pubmed/19091890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.056226
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