Synthesis and Evaluation of [N-methyl-(11)C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

[(11)C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with positron emission tomography (PET), but its metabolism to [N-methyl-(11)C]N-desmethyl-loperamide ([(11)C]dLop; [(11)C]3) precludes quantification. We considered that [(11)C]3 might itself be a superior radiotracer fo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lazarova, Neva, Zoghbi, Sami S., Hong, Jinsoo, Seneca, Nicholas, Tuan, Ed, Gladding, Robert L., Liow, Jeih-San, Taku, Andrew, Innis, Robert B., Pike, Victor W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646255/
https://ncbi.nlm.nih.gov/pubmed/18783208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800510m
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados