Synthesis and Evaluation of [N-methyl-(11)C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

[(11)C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with positron emission tomography (PET), but its metabolism to [N-methyl-(11)C]N-desmethyl-loperamide ([(11)C]dLop; [(11)C]3) precludes quantification. We considered that [(11)C]3 might itself be a superior radiotracer fo...

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Bibliografiske detaljer
Main Authors: Lazarova, Neva, Zoghbi, Sami S., Hong, Jinsoo, Seneca, Nicholas, Tuan, Ed, Gladding, Robert L., Liow, Jeih-San, Taku, Andrew, Innis, Robert B., Pike, Victor W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646255/
https://ncbi.nlm.nih.gov/pubmed/18783208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800510m
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