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P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer (11)C-N-desmethyl-loperamide
Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood-brain barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain entry of the positron emission tomographic (PET) radiotracer (11)C-N-desmethyl-loperamide ((11)C-dLop). We examin...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856602/ https://ncbi.nlm.nih.gov/pubmed/20237038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.070151 |
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