P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer (11)C-N-desmethyl-loperamide

Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood-brain barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain entry of the positron emission tomographic (PET) radiotracer (11)C-N-desmethyl-loperamide ((11)C-dLop). We examin...

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Bibliografiske detaljer
Main Authors: Kreisl, William C., Liow, Jeih-San, Kimura, Nobuyo, Seneca, Nicholas, Zoghbi, Sami S., Morse, Cheryl L., Herscovitch, Peter, Pike, Victor W., Innis, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856602/
https://ncbi.nlm.nih.gov/pubmed/20237038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.070151
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