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PET Measurement of the In Vivo Affinity of (11)C-(R)-Rolipram and the Density of Its Target, Phosphodiesterase-4, in the Brains of Conscious and Anesthetized Rats
A variety of phosphodiesterases hydrolyze and terminate the effects of the intracellular second messenger 3′,5′-cyclic adenosine monophosphate (cAMP). Phosphodiesterase subtype 4 (PDE4) is particularly abundant in the brain and has been imaged with (11)C-(R)-rolipram, a selective inhibitor of PDE4....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2791885/ https://ncbi.nlm.nih.gov/pubmed/19372471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.058305 |
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