[(11)C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice

Although still a matter of controversy, disrupted in schizophrenia protein 1 (DISC1) was suggested as a potential inhibitor of phosphodiesterase 4 (PDE4). We used Disc1 locus impairment (LI) mice to investigate the interaction between PDE4 and DISC 1 in vivo and in vitro. [(11)C](R)-Rolipram binding...

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Publicat a:J Cereb Blood Flow Metab
Autors principals: Ooms, Maarten, Tsujikawa, Tetsuya, Lohith, Talakad G, Mabins, Sanché N, Zoghbi, Sami S, Sumitomo, Akiko, Jaaro-Peled, Hanna, Kimura, Yasuyuki, Telu, Sanjay, Pike, Victor W, Tomoda, Toshifumi, Innis, Robert B, Sawa, Akira, Fujita, Masahiro
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668514/
https://ncbi.nlm.nih.gov/pubmed/29430995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18758997
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