Downregulation of Brain Phosphodiesterase Type IV Measured with (11)C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder

BACKGROUND: Phosphodiesterase type IV (PDE4), an important component of the cyclic adenosine monophosphate (cAMP) cascade, selectively metabolizes cAMP in the brain to the inactive monophosphate. Basic studies suggest that PDE4 mediates the effects of several antidepressants. This study sought to qu...

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Detalhes bibliográficos
Main Authors: Fujita, Masahiro, Hines, Christina S., Zoghbi, Sami S., Mallinger, Alan G., Dickstein, Leah P., Liow, Jeih-San, Zhang, Yi, Pike, Victor W., Drevets, Wayne C., Innis, Robert B., Zarate, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438357/
https://ncbi.nlm.nih.gov/pubmed/22677471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.04.030
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