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Whole-Body Biodistribution and Radiation Dosimetry in Monkeys and Humans of the Phosphodiesterase 4 Radioligand [(11)C](R)-Rolipram: Comparison of 2-Dimensional Planar, Bisected, and Quadrasected Image Analyses

INTRODUCTION: [(11)C](R)-Rolipram is a selective radioligand for PET (positron emission tomography) imaging of phosphodiesterase 4, an enzyme that metabolizes cAMP. The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys...

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Detalhes bibliográficos
Main Authors: Sprague, David R., Fujita, Masahiro, Ryu, Yong Hoon, Liow, Jeih-San, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577827/
https://ncbi.nlm.nih.gov/pubmed/18482687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2008.02.004
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