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PET Measurement of the In Vivo Affinity of (11)C-(R)-Rolipram and the Density of Its Target, Phosphodiesterase-4, in the Brains of Conscious and Anesthetized Rats

A variety of phosphodiesterases hydrolyze and terminate the effects of the intracellular second messenger 3′,5′-cyclic adenosine monophosphate (cAMP). Phosphodiesterase subtype 4 (PDE4) is particularly abundant in the brain and has been imaged with (11)C-(R)-rolipram, a selective inhibitor of PDE4....

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Autors principals: Itoh, Tetsuji, Abe, Kohji, Zoghbi, Sami S., Inoue, Osamu, Hong, Jinsoo, Imaizumi, Masao, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791885/
https://ncbi.nlm.nih.gov/pubmed/19372471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.058305
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