Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, Two Radioligands for Translocator Protein (18 kDa) in Human and Monkey: Implications for Positron Emission Tomographic Imaging of this Inflammation Biomarker

Ten percent of humans lack specific binding of [(11)C]PBR28 to 18 kDa translocator protein (TSPO), a biomarker for inflammation. “Non-binders” have not been reported using another TSPO radioligand, [(11)C]-(R)-PK 11195, despite its use for more than two decades. This study asked two questions: 1) Wh...

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Detalhes bibliográficos
Main Authors: Kreisl, William C., Fujita, Masahiro, Fujimura, Yota, Kimura, Nobuyo, Jenko, Kimberly J., Kannan, Pavitra, Hong, Jinsoo, Morse, Cheryl L., Zoghbi, Sami S., Gladding, Robert L., Jacobson, Steven, Oh, Unsong, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832854/
https://ncbi.nlm.nih.gov/pubmed/19948230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2009.11.056
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