Brain and Whole-body Imaging in Nonhuman Primates of [(11)C]PBR28, a Promising PET Radioligand for Peripheral Benzodiazepine Receptors

OBJECTIVES: Peripheral benzodiazepine receptors (PBRs) are upregulated on activated microglia and are thereby biomarkers of neuroinflammation. We developed a PET ligand with an aryloxyanilide structure, [O-methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine ([(11)C]PBR28), to image PB...

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Detalhes bibliográficos
Main Authors: Imaizumi, Masao, Briard, Emmanuelle, Zoghbi, Sami S., Gourley, Jonathan P., Hong, Jinsoo, Fujimura, Yota, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275117/
https://ncbi.nlm.nih.gov/pubmed/18024084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2007.09.063
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