Nuclear Receptor-Coregulator Interaction Profiling Identifies TRIP3 as a Novel Peroxisome Proliferator-activated Receptor γ Cofactor

Por Koppen, Arjen, Houtman, Rene, Pijnenburg, Dirk, Jeninga, Ellen H., Ruijtenbeek, Rob, Kalkhoven, Eric
Publicado em 2009

A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes

Por Monczor, Federico, Chatzopoulou, Antonia, Zappia, Carlos Daniel, Houtman, René, Meijer, Onno C., Fitzsimons, Carlos P.
Publicado no Front Pharmacol (2019)

SUN-LB001 Estetrol (E4) Is a Unique Estrogen with Selective Actions in Tissues Which Are Distinctly Different from the Actions of SERMs

Por Foidart, Jean-Michel, Arnal, Jean-Francois, Lenfant, Françoise, Taziaux, Mélanie, Houtman, René, Jost, Maud, Lobo, Roger
Publicado no J Endocr Soc (2019)

Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites

Por Perera, Lalith, Li, Yin, Coons, Laurel A., Houtman, Rene, van Beuningen, Rinie, Goodwin, Bonnie, Auerbach, Scott S., Teng, Christina T.
Publicado no Toxicol In Vitro (2017)

Co-activator candidate interactions for orphan nuclear receptor NR2E1

Por Corso-Díaz, Ximena, de Leeuw, Charles N., Alonso, Vivian, Melchers, Diana, Wong, Bibiana K. Y., Houtman, René, Simpson, Elizabeth M.
Publicado no BMC Genomics (2016)

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

Por Clarisse, Dorien, Thommis, Jonathan, Van Wesemael, Karlien, Houtman, René, Ratman, Dariusz, Tavernier, Jan, Offner, Fritz, Beck, Ilse, De Bosscher, Karolien
Publicado no Oncotarget (2017)

Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ER [Formula: see text] Complexes

Por Li, Yin, Perera, Lalith, Coons, Laurel A., Burns, Katherine A., Tyler Ramsey, J., Pelch, Katherine E., Houtman, René, van Beuningen, Rinie, Teng, Christina T., Korach, Kenneth S.
Publicado no Environ Health Perspect (2018)

Extending an In Vitro Panel for Estrogenicity Testing: The Added Value of Bioassays for Measuring Antiandrogenic Activities and Effects on Steroidogenesis

Por Wang, Si, Rijk, Jeroen C.W., Besselink, Harrie T., Houtman, René, Peijnenburg,  Ad A.C.M., Brouwer, Abraham, Rietjens, Ivonne M.C.M., Bovee,  Toine F.H.
Publicado no Toxicol Sci (2014)

Differential modulation of FXR activity by chlorophacinone and ivermectin analogs

Por Hsu, Chia-Wen, Hsieh, Jui-Hua, Huang, Ruili, Pijnenburg, Dirk, Khuc, Thai, Hamm, Jon, Zhao, Jinghua, Lynch, Caitlin, van Beuningen, Rinie, Chang, Xiaoqing, Houtman, Rene, Xia, Menghang
Publicado no Toxicol Appl Pharmacol (2016)

Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation

Por Viho, Eva M.G., Buurstede, Jacobus C., Mahfouz, Ahmed, Koorneef, Lisa L., van Weert, Lisa T.C.M., Houtman, René, Hunt, Hazel J., Kroon, Jan, Meijer, Onno C.
Publicado no Neuroendocrinology (2019)

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

Por Cornelison, Jeffery L., Cato, Michael L., Johnson, Alyssa M., D’Agostino, Emma H., Melchers, Diana, Patel, Anamika B., Mays, Suzanne G., Houtman, René, Ortlund, Eric A., Jui, Nathan T.
Publicado no Bioorg Med Chem Lett (2020)

Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of Pregnane X Receptor

Por Murayama, Norie, van Beuningen, Rinie, Suemizu, Hiroshi, Guillouzo, Christiane Guguen, Shibata, Norio, Yajima, Kanako, Utoh, Masahiro, Shimizu, Makiko, Chesné, Christophe, Nakamura, Masato, Guengerich, F. Peter, Houtman, René, Yamazaki, Hiroshi
Publicado em 2014

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment

Por Li, Yin, Coons, Laurel A., Houtman, René, Carlson, Kathryn E., Martin, Teresa A., Mayne, Christopher G., Melchers, Diana, Jefferson, Tanner B., Ramsey, J. Tyler, Katzenellenbogen, John A., Korach, Kenneth S.
Publicado no Sci Signal (2020)

The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity

Por Koorneef, Lisa L, Kroon, Jan, Viho, Eva M G, Wahl, Lucas F, Heckmans, Kim M L, van Dorst, Marloes M A R, Hoekstra, Menno, Houtman, René, Hunt, Hazel, Meijer, Onno C
Publicado no J Endocrinol (2020)

OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain

Por Nwachukwu, Jerome, Min, Jian, Srinivasan, Sathish K, Rangarajan, Erumbi, Guillen, Valeria Sanabria, Ziegler, Yvonne, Carlson, Kathryn, Hou, Yingwei, Kim, Sung Hoon, Izard, Tina, Houtman, Rene, Katzenellenbogen, Benita S, Nettles, Kendall W, Katzenellenbogen, John A
Publicado no J Endocr Soc (2020)

The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

Por Chantalat, Elodie, Boudou, Frédéric, Laurell, Henrik, Palierne, Gaëlle, Houtman, René, Melchers, Diana, Rochaix, Philippe, Filleron, Thomas, Stella, Alexandre, Burlet-Schiltz, Odile, Brouchet, Anne, Flouriot, Gilles, Métivier, Raphaël, Arnal, Jean-François, Fontaine, Coralie, Lenfant, Françoise
Publicado no Breast Cancer Res (2016)

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

Por Guo, Shanchun, Zhang, Changde, Bratton, Melyssa, Mottamal, Madhusoodanan, Liu, Jiawang, Ma, Peng, Zheng, Shilong, Zhong, Qiu, Yang, Lin, Wiese, Thomas E., Wu, Yong, Ellis, Matthew J., Matossian, Margarite, Burow, Matthew E., Miele, Lucio, Houtman, René, Wang, Guangdi
Publicado no Oncotarget (2018)

Predictive features of ligand‐specific signaling through the estrogen receptor

Por Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W
Publicado no Mol Syst Biol (2016)

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

Por Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.
Publicado em 2013

The nuclear receptor PPARg controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory

Por Daniel, Bence, Nagy, Gergely, Czimmerer, Zsolt, Horvath, Attila, Hammers, David W., Cuaranta-Monroy, Ixchelt, Poliska, Szilard, Tzerpos, Petros, Kolostyak, Zsuzsanna, Hays, Tristan T., Patsalos, Andreas, Houtman, René, Sauer, Sascha, Francois-Deleuze, Jean, Rastinejad, Fraydoon, Balint, Balint L., Sweeney, H. Lee, Nagy, Laszlo
Publicado no Immunity (2018)