A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment

A homozygous missense mutation in the gene encoding the estrogen receptor α (ERα) was previously identified in a female patient with estrogen insensitivity syndrome. We investigated the molecular features underlying the impaired transcriptional response of this mutant (ERα-Q375H) and four other miss...

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Publicado no:Sci Signal
Main Authors: Li, Yin, Coons, Laurel A., Houtman, René, Carlson, Kathryn E., Martin, Teresa A., Mayne, Christopher G., Melchers, Diana, Jefferson, Tanner B., Ramsey, J. Tyler, Katzenellenbogen, John A., Korach, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597377/
https://ncbi.nlm.nih.gov/pubmed/32963012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw4653
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