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A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment
A homozygous missense mutation in the gene encoding the estrogen receptor α (ERα) was previously identified in a female patient with estrogen insensitivity syndrome. We investigated the molecular features underlying the impaired transcriptional response of this mutant (ERα-Q375H) and four other miss...
Shranjeno v:
| izdano v: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7597377/ https://ncbi.nlm.nih.gov/pubmed/32963012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw4653 |
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