A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment

A homozygous missense mutation in the gene encoding the estrogen receptor α (ERα) was previously identified in a female patient with estrogen insensitivity syndrome. We investigated the molecular features underlying the impaired transcriptional response of this mutant (ERα-Q375H) and four other miss...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Signal
Autori principali: Li, Yin, Coons, Laurel A., Houtman, René, Carlson, Kathryn E., Martin, Teresa A., Mayne, Christopher G., Melchers, Diana, Jefferson, Tanner B., Ramsey, J. Tyler, Katzenellenbogen, John A., Korach, Kenneth S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597377/
https://ncbi.nlm.nih.gov/pubmed/32963012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw4653
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi