The nuclear receptor PPARg controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory

Macrophages polarize into distinct phenotypes in response to complex environmental cues. We found that the nuclear receptor PPARγ drove robust phenotypic changes in macrophages upon repeated stimulation with interleukin (IL)-4. The functions of PPARγ on macrophage polarization in this setting were i...

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Publicado no:Immunity
Principais autores: Daniel, Bence, Nagy, Gergely, Czimmerer, Zsolt, Horvath, Attila, Hammers, David W., Cuaranta-Monroy, Ixchelt, Poliska, Szilard, Tzerpos, Petros, Kolostyak, Zsuzsanna, Hays, Tristan T., Patsalos, Andreas, Houtman, René, Sauer, Sascha, Francois-Deleuze, Jean, Rastinejad, Fraydoon, Balint, Balint L., Sweeney, H. Lee, Nagy, Laszlo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197058/
https://ncbi.nlm.nih.gov/pubmed/30332629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.09.005
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