The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages

Retinoid X receptor (RXR) is an obligate heterodimeric partner of several nuclear receptors (NRs), and as such a central component of NR signaling regulating the immune and metabolic phenotype of macrophages. Importantly, the binding motifs of RXR heterodimers are enriched in the tissue-selective op...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Daniel, Bence, Nagy, Gergely, Horvath, Attila, Czimmerer, Zsolt, Cuaranta-Monroy, Ixchelt, Poliska, Szilard, Hays, Tristan T, Sauer, Sascha, Francois-Deleuze, Jean, Nagy, Laszlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961189/
https://ncbi.nlm.nih.gov/pubmed/29506156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky157
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