The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcription factor is required for the direct...

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Publicado no:Immunity
Main Authors: Czimmerer, Zsolt, Daniel, Bence, Horvath, Attila, Rückerl, Dominik, Nagy, Gergely, Kiss, Mate, Peloquin, Matthew, Budai, Marietta M., Cuaranta-Monroy, Ixchelt, Simandi, Zoltan, Steiner, Laszlo, Nagy, Bela, Poliska, Szilard, Banko, Csaba, Bacso, Zsolt, Schulman, Ira G., Sauer, Sascha, Deleuze, Jean-Francois, Allen, Judith E., Benko, Szilvia, Nagy, Laszlo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772169/
https://ncbi.nlm.nih.gov/pubmed/29343442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.12.010
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