PIP(2)-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations

Por Stansfeld, Phillip J., Hopkinson, Richard, Ashcroft, Frances M., Sansom, Mark S. P.
Publicado em 2009

Targeting histone lysine demethylases — Progress, challenges, and the future()

Por Thinnes, Cyrille C., England, Katherine S., Kawamura, Akane, Chowdhury, Rasheduzzaman, Schofield, Christopher J., Hopkinson, Richard J.
Publicado no Biochim Biophys Acta Gene Regul Mech (2014)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Por Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Schiller, Rachel, Ge, Wei, Kawamura, Akane, Schofield, Christopher J.
Publicado no Nat Commun (2016)

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

Por Williams, Sophie T, Walport, Louise J, Hopkinson, Richard J, Madden, Sarah K, Chowdhury, Rasheduzzaman, Schofield, Christopher J, Kawamura, Akane
Publicado no Epigenetics (2015)

Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase

Por Walport, Louise J., Hopkinson, Richard J., Vollmar, Melanie, Madden, Sarah K., Gileadi, Carina, Oppermann, Udo, Schofield, Christopher J., Johansson, Catrine
Publicado em 2014

Investigations on the Oxygen Dependence of a 2-Oxoglutarate Histone Demethylase

Por Sánchez-Fernández, Elena M., Tarhonskaya, Hanna, Al-Qahtani, Khalid, Hopkinson, Richard J., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily
Publicado no Biochem J (2013)

Small molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry

Por Mackeen, Mukram M., Kramer, Holger B., Chang, Kai-Hsuan, Coleman, Matthew L., Hopkinson, Richard J., Schofield, Christopher J., Kessler, Benedikt M.
Publicado no J Proteome Res (2010)

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

Por Hopkinson, Richard J., Leung, Ivanhoe K. H., Smart, Tristan J., Rose, Nathan R., Henry, Luc, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado no PLoS One (2015)

Is JmjC Oxygenase Catalysis Limited to Demethylation?**

Por Hopkinson, Richard J, Walport, Louise J, Münzel, Martin, Rose, Nathan R, Smart, Tristan J, Kawamura, Akane, Claridge, Timothy D W, Schofield, Christopher J
Publicado em 2013

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Por White, Mark D., Klecker, Maria, Hopkinson, Richard J., Weits, Daan A., Mueller, Carolin, Naumann, Christin, O'Neill, Rebecca, Wickens, James, Yang, Jiayu, Brooks-Bartlett, Jonathan C., Garman, Elspeth F., Grossmann, Tom N., Dissmeyer, Nico, Flashman, Emily
Publicado no Nat Commun (2017)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Por Kawamura, Akane, Münzel, Martin, Kojima, Tatsuya, Yapp, Clarence, Bhushan, Bhaskar, Goto, Yuki, Tumber, Anthony, Katoh, Takayuki, King, Oliver N. F., Passioura, Toby, Walport, Louise J., Hatch, Stephanie B., Madden, Sarah, Müller, Susanne, Brennan, Paul E., Chowdhury, Rasheduzzaman, Hopkinson, Richard J., Suga, Hiroaki, Schofield, Christopher J.
Publicado no Nat Commun (2017)

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

Por Feng, Tianshu, Yamamoto, Atsushi, Wilkins, Sarah E., Sokolova, Elizaveta, Yates, Luke A., Münzel, Martin, Singh, Pooja, Hopkinson, Richard J., Fischer, Roman, Cockman, Matthew E., Shelley, Jake, Trudgian, David C., Schödel, Johannes, McCullagh, James S.O., Ge, Wei, Kessler, Benedikt M., Gilbert, Robert J., Frolova, Ludmila Y., Alkalaeva, Elena, Ratcliffe, Peter J., Schofield, Christopher J., Coleman, Mathew L.
Publicado em 2014

The Plant Growth Regulator Daminozide is a Selective Inhibitor of the Human KDM2/7 Histone Demethylases

Por Rose, Nathan R., Woon, Esther C.Y., Tumber, Anthony, Walport, Louise J., Chowdhury, Rasheduzzaman, Li, Xuan Shirley, King, Oliver N.F., Lejeune, Clarisse, Ng, Stanley S., Krojer, Tobias, Chan, Mun Chiang, Rydzik, Anna M., Hopkinson, Richard J., Che, Ka Hing, Daniel, Michelle, Strain-Damerell, Claire, Gileadi, Carina, Kochan, Grazyna, Leung, Ivanhoe K. H., Dunford, James, Yeoh, Kar Kheng, Ratcliffe, Peter J., Burgess-Brown, Nicola, von Delft, Frank, Muller, Susanne, Marsden, Brian, Brennan, Paul E., McDonough, Michael A., Oppermann, Udo, Klose, Robert J., Schofield, Christopher J., Kawamura, Akane
Publicado no J Med Chem (2012)

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation

Por Hopkinson, Richard J., Tumber, Anthony, Yapp, Clarence, Chowdhury, Rasheduzzaman, Aik, WeiShen, Che, Ka Hing, Li, Xuan Shirley, Kristensen, Jan B. L., King, Oliver N. F., Chan, Mun Chiang, Yeoh, Kar Kheng, Choi, Hwanho, Walport, Louise J., Thinnes, Cyrille C., Bush, Jacob T., Lejeune, Clarisse, Rydzik, Anna M., Rose, Nathan R., Bagg, Eleanor A., McDonough, Michael A., Krojer, Tobias, Yue, Wyatt W., Ng, Stanley S., Olsen, Lars, Brennan, Paul E., Oppermann, Udo, Muller-Knapp, Susanne, Klose, Robert J., Ratcliffe, Peter J., Schofield, Christopher J., Kawamura, Akane
Publicado no Chem Sci (2013)