The Plant Growth Regulator Daminozide is a Selective Inhibitor of the Human KDM2/7 Histone Demethylases

The JmjC oxygenases catalyse the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Rose, Nathan R., Woon, Esther C.Y., Tumber, Anthony, Walport, Louise J., Chowdhury, Rasheduzzaman, Li, Xuan Shirley, King, Oliver N.F., Lejeune, Clarisse, Ng, Stanley S., Krojer, Tobias, Chan, Mun Chiang, Rydzik, Anna M., Hopkinson, Richard J., Che, Ka Hing, Daniel, Michelle, Strain-Damerell, Claire, Gileadi, Carina, Kochan, Grazyna, Leung, Ivanhoe K. H., Dunford, James, Yeoh, Kar Kheng, Ratcliffe, Peter J., Burgess-Brown, Nicola, von Delft, Frank, Muller, Susanne, Marsden, Brian, Brennan, Paul E., McDonough, Michael A., Oppermann, Udo, Klose, Robert J., Schofield, Christopher J., Kawamura, Akane
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673902/
https://ncbi.nlm.nih.gov/pubmed/22724510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300677j
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