Drug metabolism and pharmacokinetics quick guide

Por Khojasteh, Siamak Cyrus., Wong, Harvey., Hop, Cornelis E.C.A.
Publicado em 2011

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling

Por Mao, Jialin, Doshi, Utkarsh, Wright, Matthew, Hop, Cornelis E. C. A., Li, Albert P., Chen, Yuan
Publicado no CPT Pharmacometrics Syst Pharmacol (2018)

A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor...

Por Malhi, Vikram, Colburn, Dawn, Williams, Sarah J., Hop, Cornelis E. C. A., Dresser, Mark J., Chandra, Priya, Graham, Richard A.
Publicado no Cancer Chemother Pharmacol (2016)

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Sp...

Por Prasad, Bhagwat, Evers, Raymond, Gupta, Anshul, Hop, Cornelis E. C. A., Salphati, Laurent, Shukla, Suneet, Ambudkar, Suresh V., Unadkat, Jashvant D.
Publicado em 2014

A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834

Por Sodhi, Jasleen K., Wong, Susan, Kirkpatrick, Donald S., Liu, Lichuan, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A., Barr, John T., Jones, Jeffrey P., Halladay, Jason S.
Publicado no Drug Metab Dispos (2015)

An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

Por Shah, Pranav, Kerns, Edward, Nguyen, Dac-Trung, Obach, R. Scott, Wang, Amy Q., Zakharov, Alexey, McKew, John, Simeonov, Anton, Hop, Cornelis E. C. A., Xu, Xin
Publicado no Drug Metab Dispos (2016)

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

Por Graham, Richard A, Hop, Cornelis E C A, Borin, Marie T, Lum, Bert L, Colburn, Dawn, Chang, Ilsung, Shin, Young G, Malhi, Vikram, Low, Jennifer A, Dresser, Mark J
Publicado em 2012

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

Por Prasad, Bhagwat, Gaedigk, Andrea, Vrana, Marc, Gaedigk, Roger, Leeder, J. Steven, Salphati, Laurent, Chu, Xiaoyan, Xiao, Guangqing, Hop, Cornelis E.C.A., Evers, Raymond, Gan, Lawrence, Unadkat, Jashvant D.
Publicado no Clin Pharmacol Ther (2016)

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

Por Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S., Pillow, Thomas H., Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D., Erickson, Hans K., Hop, Cornelis E. C. A., Khojasteh, S. Cyrus
Publicado no Drug Metab Dispos (2016)

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

Por Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E. C. A., Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G., Kumer, Sean C., Unadkat, Jashvant D.
Publicado no Drug Metab Dispos (2018)

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

Por Wang, Li, Collins, Carol, Kelly, Edward J., Chu, Xiaoyan, Ray, Adrian S., Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Lai, Yurong, Liao, Mingxiang, Mathias, Anita, Evers, Raymond, Humphreys, William, Hop, Cornelis E. C. A., Kumer, Sean C., Unadkat, Jashvant D.
Publicado no Drug Metab Dispos (2016)

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics

Por Billington, Sarah, Ray, Adrian S., Salphati, Laurent, Xiao, Guangqing, Chu, Xiaoyan, Humphreys, W. Griffith, Liao, Mingxiang, Lee, Caroline A., Mathias, Anita, Hop, Cornelis E. C. A., Rowbottom, Christopher, Evers, Raymond, Lai, Yurong, Kelly, Edward J., Prasad, Bhagwat, Unadkat, Jashvant D.
Publicado no Drug Metab Dispos (2018)

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates

Por Zhang, Donglu, Pillow, Thomas H., Ma, Yong, Cruz-Chuh, Josefa dela, Kozak, Katherine R., Sadowsky, Jack D., Lewis Phillips, Gail D., Guo, Jun, Darwish, Martine, Fan, Peter, Chen, Jingtian, He, Changrong, Wang, Tao, Yao, Hui, Xu, Zijin, Chen, Jinhua, Wai, John, Pei, Zhonghua, Hop, Cornelis E. C. A., Khojasteh, S. Cyrus, Dragovich, Peter S.
Publicado no ACS Med Chem Lett (2016)