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Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1, and multidrug resistance-linked P-glycoprotein (P-gp) or ABCB1 was quantified in frozen human livers (n = 64) and cryopreserved human hepatocytes (n = 12) by a validated li...

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Detalhes bibliográficos
Main Authors: Prasad, Bhagwat, Evers, Raymond, Gupta, Anshul, Hop, Cornelis E. C. A., Salphati, Laurent, Shukla, Suneet, Ambudkar, Suresh V., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876790/
https://ncbi.nlm.nih.gov/pubmed/24122874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.053819
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