Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates

Por Zhang, Donglu, Pillow, Thomas H., Ma, Yong, Cruz-Chuh, Josefa dela, Kozak, Katherine R., Sadowsky, Jack D., Lewis Phillips, Gail D., Guo, Jun, Darwish, Martine, Fan, Peter, Chen, Jingtian, He, Changrong, Wang, Tao, Yao, Hui, Xu, Zijin, Chen, Jinhua, Wai, John, Pei, Zhonghua, Hop, Cornelis E. C. A., Khojasteh, S. Cyrus, Dragovich, Peter S.
Publicado no ACS Med Chem Lett (2016)

Stabilizing a Tubulysin Antibody–Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors

Por Staben, Leanna R., Yu, Shang-Fan, Chen, Jinhua, Yan, Gang, Xu, Zijin, Del Rosario, Geoffrey, Lau, Jeffrey T., Liu, Luna, Guo, Jun, Zheng, Bing, Cruz-Chuh, Josefa dela, Lee, Byoung-Chul, Ohri, Rachana, Cai, Wenwen, Zhou, Hongxiang, Kozak, Katherine R., Xu, Keyang, Lewis Phillips, Gail D., Lu, Jiawei, Wai, John, Polson, Andrew G., Pillow, Thomas H.
Publicado no ACS Med Chem Lett (2017)