Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates

[Image: see text] Disulfide bonds could be valuable linkers for a variety of therapeutic applications requiring tunable cleavage between two parts of a molecule (e.g., antibody–drug conjugates). The in vitro linker immolation of β-mercaptoethyl-carbamate disulfides and DNA alkylation properties of a...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhang, Donglu, Pillow, Thomas H., Ma, Yong, Cruz-Chuh, Josefa dela, Kozak, Katherine R., Sadowsky, Jack D., Lewis Phillips, Gail D., Guo, Jun, Darwish, Martine, Fan, Peter, Chen, Jingtian, He, Changrong, Wang, Tao, Yao, Hui, Xu, Zijin, Chen, Jinhua, Wai, John, Pei, Zhonghua, Hop, Cornelis E. C. A., Khojasteh, S. Cyrus, Dragovich, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108036/
https://ncbi.nlm.nih.gov/pubmed/27882196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00233
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