Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase 1 and phase 2 drug-metabolizing enzymes (DMEs) in S9 fractions of alcoholic (n = 27) or hepatitis C (HCV, n = 30) cirrhot...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E. C. A., Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G., Kumer, Sean C., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987995/
https://ncbi.nlm.nih.gov/pubmed/29695616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.080523
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