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Optimized Approaches for Quantification of Drug Transporters in Tissues and Cells by MRM Proteomics
Drug transporter expression in tissues (in vivo) usually differs from that in cell lines used to measure transporter activity (in vitro). Therefore, quantification of transporter expression in tissues and cell lines is important to develop scaling factor for in vitro to in vivo extrapolation (IVIVE)...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070263/ https://ncbi.nlm.nih.gov/pubmed/24752720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9602-y |
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