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Critical issues and optimized practices in quantification of protein abundance level to determine inter-individual variability in DMET proteins by LC-MS/MS proteomics

Protein quantification data on drug metabolizing enzymes and transporters (collectively referred as DMET proteins) in human tissues are useful in predicting interindividual variability in drug disposition. While targeted proteomics is an emerging technique for quantification of DMET proteins, the me...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: Bhatt, Deepak Kumar, Prasad, Bhagwat
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816727/
https://ncbi.nlm.nih.gov/pubmed/28833066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.819
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