Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis

par Cameron, Scott, McLuskey, Karen, Chamberlayne, Rachel, Hallyburton, Irene, Hunter, William N.
Publié 2005

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

par Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publié 2010

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

par Paveley, Ross A., Mansour, Nuha R., Hallyburton, Irene, Bleicher, Leo S., Benn, Alex E., Mikic, Ivana, Guidi, Alessandra, Gilbert, Ian H., Hopkins, Andrew L., Bickle, Quentin D.
Publié 2012

Quinol derivatives as potential trypanocidal agents

par Capes, Amy, Patterson, Stephen, Wyllie, Susan, Hallyburton, Irene, Collie, Iain T., McCarroll, Andrew J., Stevens, Malcolm F.G., Frearson, Julie A., Wyatt, Paul G., Fairlamb, Alan H., Gilbert, Ian H.
Publié 2012

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

par De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Publié 2013

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

par De Rycker, Manu, Hallyburton, Irene, Thomas, John, Campbell, Lorna, Wyllie, Susan, Joshi, Dhananjay, Cameron, Scott, Gilbert, Ian H., Wyatt, Paul G., Frearson, Julie A., Fairlamb, Alan H., Gray, David W.
Publié dans Antimicrob Agents Chemother (2014)

Screening a protein kinase inhibitor library against Plasmodium falciparum

par Hallyburton, Irene, Grimaldi, Raffaella, Woodland, Andrew, Baragaña, Beatriz, Luksch, Torsten, Spinks, Daniel, James, Daniel, Leroy, Didier, Waterson, David, Fairlamb, Alan H., Wyatt, Paul G., Gilbert, Ian H., Frearson, Julie A.
Publié dans Malar J (2017)

Escaping from Flatland: Antimalarial Activity of sp(3)-Rich Bridged Pyrrolidine Derivatives

par Cox, Brian, Duffy, James, Zdorichenko, Victor, Bellanger, Corentin, Hurcum, Jessica, Laleu, Benoît, Booker-Milburn, Kevin I., Elliott, Luke D., Robertson-Ralph, Michael, Swain, Christopher J., Bishop, Stephen J., Hallyburton, Irene, Anderson, Mark
Publié dans ACS Med Chem Lett (2020)

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

par Smith, Victoria C, Cleghorn, Laura A T, Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T, Yi Mok, N, Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H, Frearson, Julie A, Read, Kevin D, Gilbert, Ian H, Wyatt, Paul G
Publié 2011

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

par Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publié dans J Med Chem (2015)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

par Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publié dans ChemMedChem (2015)

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

par Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Publié dans ChemMedChem (2015)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

par Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publié dans J Med Chem (2018)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

par Corpas-Lopez, Victoriano, Moniz, Sonia, Thomas, Michael, Wall, Richard J., Torrie, Leah S., Zander-Dinse, Dorothea, Tinti, Michele, Brand, Stephen, Stojanovski, Laste, Manthri, Sujatha, Hallyburton, Irene, Zuccotto, Fabio, Wyatt, Paul G., De Rycker, Manu, Horn, David, Ferguson, Michael A. J., Clos, Joachim, Read, Kevin D., Fairlamb, Alan H., Gilbert, Ian H., Wyllie, Susan
Publié dans ACS Infect Dis (2018)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

par Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publié 2011

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Tre...

par Brand, Stephen, Norcross, Neil R., Thompson, Stephen, Harrison, Justin R., Smith, Victoria C., Robinson, David A., Torrie, Leah S., McElroy, Stuart P., Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., van Aalten, Daan, Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publié dans J Med Chem (2014)

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

par Baragaña, Beatriz, Norcross, Neil R., Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C., Wyatt, Paul G., Delves, Michael J., Meister, Stephan, Duffy, Sandra, Avery, Vicky M., Winzeler, Elizabeth A., Sinden, Robert E., Wittlin, Sergio, Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Waterson, David, Campbell, Simon F., Willis, Paul, Read, Kevin D., Gilbert, Ian H.
Publié dans J Med Chem (2016)

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

par Hewitt, Stephen Nakazawa, Dranow, David M., Horst, Benjamin G., Abendroth, Jan A., Forte, Barbara, Hallyburton, Irene, Jansen, Chimed, Baragaña, Beatriz, Choi, Ryan, Rivas, Kasey L., Hulverson, Matthew A., Dumais, Mitchell, Edwards, Thomas E., Lorimer, Donald D., Fairlamb, Alan H., Gray, David W., Read, Kevin D., Lehane, Adele M., Kirk, Kiaran, Myler, Peter J., Wernimont, Amy, Walpole, Chris, Stacy, Robin, Barrett, Lynn K., Gilbert, Ian H., Van Voorhis, Wesley C.
Publié dans ACS Infect Dis (2016)

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

par Norcross, Neil R., Wilson, Caroline, Baragaña, Beatriz, Hallyburton, Irene, Osuna‐Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Fletcher, Daniel, Sinden, Robert, Delves, Michael, Ruecker, Andrea, Duffy, Sandra, Meister, Stephan, Antonova‐Koch, Yevgeniya, Crespo, Benigno, de Cózar, Cristina, Sanz, Laura M., Gamo, Francisco Javier, Avery, Vicky M., Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Winzeler, Elizabeth A., Waterson, David, Campbell, Simon F., Willis, Paul A., Read, Kevin D., Gilbert, Ian H.
Publié dans ChemMedChem (2019)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

par Frearson, Julie A., Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A.T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Hallyburton, Irene, Mpamhanga, Chidochangu P., Brannigan, James A., Wilkinson, Anthony J., Hodgkinson, Michael, Hui, Raymond, Qiu, Wei, Raimi, Olawale G., van Aalten, Daan M. F., Brenk, Ruth, Gilbert, Ian H., Read, Kevin D., Fairlamb, Alan H., Ferguson, Michael A. J., Smith, Deborah F., Wyatt, Paul G.
Publié 2010