Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

[Image: see text] Plasmodium falciparum (Pf) prolyl-tRNA synthetase (ProRS) is one of the few chemical-genetically validated drug targets for malaria, yet highly selective inhibitors have not been described. In this paper, approximately 40,000 compounds were screened to identify compounds that selec...

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Detaylı Bibliyografya
Yayımlandı:ACS Infect Dis
Asıl Yazarlar: Hewitt, Stephen Nakazawa, Dranow, David M., Horst, Benjamin G., Abendroth, Jan A., Forte, Barbara, Hallyburton, Irene, Jansen, Chimed, Baragaña, Beatriz, Choi, Ryan, Rivas, Kasey L., Hulverson, Matthew A., Dumais, Mitchell, Edwards, Thomas E., Lorimer, Donald D., Fairlamb, Alan H., Gray, David W., Read, Kevin D., Lehane, Adele M., Kirk, Kiaran, Myler, Peter J., Wernimont, Amy, Walpole, Chris, Stacy, Robin, Barrett, Lynn K., Gilbert, Ian H., Van Voorhis, Wesley C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2016
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241706/
https://ncbi.nlm.nih.gov/pubmed/27798837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00078
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