Determination of HER2 Amplification Status on Tumour DNA by Digital PCR

Por Garcia-Murillas, Isaac, Lambros, Maryou, Turner, Nicholas C.
Publicado em 2013

An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

Por Garcia-Murillas, Isaac, Sharpe, Rachel, Pearson, Alex, Campbell, James, Natrajan, Rachael, Ashworth, Alan, Turner, Nicholas C
Publicado em 2013

Reproducibility of Digital PCR Assays for Circulating Tumor DNA Analysis in Advanced Breast Cancer

Por Hrebien, Sarah, O’Leary, Ben, Beaney, Matthew, Schiavon, Gaia, Fribbens, Charlotte, Bhambra, Amarjit, Johnson, Richard, Garcia-Murillas, Isaac, Turner, Nicholas
Publicado no PLoS One (2016)

Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition

Por López-Knowles, Elena, Segal, Corrinne V, Gao, Qiong, Garcia-Murillas, Isaac, Turner, Nicholas C, Smith, Ian, Martin, Lesley-Ann, Dowsett, Mitch
Publicado no Breast Cancer Res (2014)

Non-invasive detection of HER2 amplification with plasma DNA Digital PCR

Por Gevensleben, Heidrun, Garcia-Murillas, Isaac, Graeser, Monika K, Schiavon, Gaia, Osin, Peter, Parton, Marina, Smith, Ian E, Ashworth, Alan, Turner, Nicholas C
Publicado no Clin Cancer Res (2013)

Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer

Por Fribbens, Charlotte, Garcia Murillas, Isaac, Beaney, Matthew, Hrebien, Sarah, O’Leary, Ben, Kilburn, Lucy, Howarth, Karen, Epstein, Michael, Green, Emma, Rosenfeld, Nitzan, Ring, Alistair, Johnston, Stephen, Turner, Nicholas
Publicado no Ann Oncol (2018)

Predicting response to radical (chemo)radiotherapy with circulating HPV DNA in locally advanced head and neck squamous carcinoma

Por Lee, Jen Y, Garcia-Murillas, Isaac, Cutts, Rosalind J, De Castro, David Gonzalez, Grove, Lorna, Hurley, Tara, Wang, Fuqiang, Nutting, Christopher, Newbold, Katie, Harrington, Kevin, Turner, Nicholas, Bhide, Shreerang
Publicado no Br J Cancer (2017)

Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations

Por Lopez-Knowles, Elena, Pearson, Alex, Schuster, Gene, Gellert, Pascal, Ribas, Ricardo, Yeo, Belinda, Cutts, Ros, Buus, Richard, Garcia-Murillas, Isaac, Haynes, Ben, Martin, Lesley-Ann, Smith, Ian, Turner, Nick, Dowsett, Mitch
Publicado no Br J Cancer (2018)

The genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trial

Por O’Leary, Ben, Cutts, Rosalind J, Liu, Yuan, Hrebien, Sarah, Huang, Xin, Fenwick, Kerry, André, Fabrice, Loibl, Sibylle, Loi, Sherene, Garcia-Murillas, Isaac, Cristofanilli, Massimo, Huang Bartlett, Cynthia, Turner, Nicholas C
Publicado no Cancer Discov (2018)

Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach

Por Pender, Alexandra, Garcia-Murillas, Isaac, Rana, Sareena, Cutts, Rosalind J., Kelly, Gavin, Fenwick, Kerry, Kozarewa, Iwanka, Gonzalez de Castro, David, Bhosle, Jaishree, O’Brien, Mary, Turner, Nicholas C., Popat, Sanjay, Downward, Julian
Publicado no PLoS One (2015)

Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer

Por O’Leary, Ben, Hrebien, Sarah, Morden, James P., Beaney, Matthew, Fribbens, Charlotte, Huang, Xin, Liu, Yuan, Bartlett, Cynthia Huang, Koehler, Maria, Cristofanilli, Massimo, Garcia-Murillas, Isaac, Bliss, Judith M., Turner, Nicholas C.
Publicado no Nat Commun (2018)

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels

Por Raghu, Padinjat, Coessens, Elise, Manifava, Maria, Georgiev, Plamen, Pettitt, Trevor, Wood, Eleanor, Garcia-Murillas, Isaac, Okkenhaug, Hanneke, Trivedi, Deepti, Zhang, Qifeng, Razzaq, Azam, Zaid, Ola, Wakelam, Michael, O'Kane, Cahir J, Ktistakis, Nicholas
Publicado em 2009

Modelling therapy resistance in BRCA1/2 mutant cancers

Por Dréan, Amy, Williamson, Chris T., Brough, Rachel, Brandsma, Inger, Menon, Malini, Konde, Asha, Garcia-Murillas, Isaac, Pemberton, Helen N., Frankum, Jessica, Rafiq, Rumana, Badham, Nick, Campbell, James, Gulati, Aditi, Turner, Nicholas C., Pettitt, Stephen J., Ashworth, Alan, Lord, Christopher J.
Publicado no Mol Cancer Ther (2017)

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Por Schiavon, Gaia, Hrebien, Sarah, Garcia-Murillas, Isaac, Cutts, Rosalind J, Pearson, Alex, Tarazona, Noelia, Fenwick, Kerry, Kozarewa, Iwanka, Lopez-Knowles, Elena, Ribas, Ricardo, Nerurkar, Ashutosh, Osin, Peter, Chandarlapaty, Sarat, Martin, Lesley-Ann, Dowsett, Mitch, Smith, Ian E, Turner, Nicholas C.
Publicado no Sci Transl Med (2015)

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

Por Herrera-Abreu, Maria Teresa, Palafox, Marta, Asghar, Uzma, Rivas, Martín A., Cutts, Rosalind J., Garcia-Murillas, Isaac, Pearson, Alex, Guzman, Marta, Rodriguez, Olga, Grueso, Judit, Bellet, Meritxell, Cortés, Javier, Elliott, Richard, Pancholi, Sunil, Lord, Christopher J., Baselga, José, Dowsett, Mitch, Martin, Lesley-Ann, Turner, Nicholas C., Serra, Violeta
Publicado no Cancer Res (2016)

Serial Next Generation Sequencing of Circulating Cell Free DNA Evaluating Tumour Clone Response To Molecularly Targeted Drug Administration

Por Frenel, Jean Sebastien, Carreira, Suzanne, Goodall, Jane, Roda, Desam, Perez-Lopez, Raquel, Tunariu, Nina, Riisnaes, Ruth, Miranda, Susana, Figueiredo, Ines, NavaRodrigues, Daniel, Smith, Alan, Leux, Christophe, Garcia-Murillas, Isaac, Ferraldeschi, Roberta, Lorente, David, Mateo, Joaquin, Ong, Michael, Yap, Timothy A, Banerji, Udai, Tandefelt, Delila Gasi, Turner, Nick, Attard, Gerhardt, de Bono, Johann S
Publicado no Clin Cancer Res (2015)

The spatio-temporal evolution of lymph node spread in early breast cancer

Por Barry, Peter, Vatsiou, Alexandra, Spiteri, Inmaculada, Nichol, Daniel, Cresswell, George D., Acar, Ahmet, Trahearn, Nicholas, Hrebien, Sarah, Garcia-Murillas, Isaac, Chkhaidze, Kate, Ermini, Luca, Huntingford, Ian Said, Cottom, Hannah, Zabaglo, Lila, Koelble, Konrad, Khalique, Saira, Rusby, Jennifer, Muscara, Francesca, Dowsett, Mitch, Maley, Carlo, Natrajan, Rachael, Yuan, Yinyin, Schiavon, Gaia, Turner, Nicholas, Sottoriva, Andrea
Publicado no Clin Cancer Res (2018)

Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer

Por Garcia-Murillas, Isaac, Chopra, Neha, Comino-Méndez, Iñaki, Beaney, Matthew, Tovey, Holly, Cutts, Rosalind J., Swift, Claire, Kriplani, Divya, Afentakis, Maria, Hrebien, Sarah, Walsh-Crestani, Giselle, Barry, Peter, Johnston, Stephen R. D., Ring, Alistair, Bliss, Judith, Russell, Simon, Evans, Abigail, Skene, Anthony, Wheatley, Duncan, Dowsett, Mitch, Smith, Ian E., Turner, Nicholas C.
Publicado no JAMA Oncol (2019)

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

Por Martin, Lesley-Ann, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Pancholi, Sunil, Tenev, Tencho, Gellert, Pascal, Buluwela, Laki, Harrod, Alison, Thornhill, Allan, Nikitorowicz-Buniak, Joanna, Bhamra, Amandeep, Turgeon, Marc-Olivier, Poulogiannis, George, Gao, Qiong, Martins, Vera, Hills, Margaret, Garcia-Murillas, Isaac, Fribbens, Charlotte, Patani, Neill, Li, Zheqi, Sikora, Matthew J., Turner, Nicholas, Zwart, Wilbert, Oesterreich, Steffi, Carroll, Jason, Ali, Simak, Dowsett, Mitch
Publicado no Nat Commun (2017)

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer

Por Weigelt, Britta, Comino-Méndez, Iñaki, de Bruijn, Ino, Tian, Lei, Meisel, Jane L, García-Murillas, Isaac, Fribbens, Charlotte, Cutts, Ros, Martelotto, Luciano G, Ng, Charlotte KY, Lim, Raymond S, Selenica, Pier, Piscuoglio, Salvatore, Aghajanian, Carol, Norton, Larry, Murali, Rajmohan, Hyman, David M, Borsu, Laetitia, Arcila, Maria E, Konner, Jason, Reis-Filho, Jorge S, Greenberg, Roger A, Robson, Mark E, Turner, Nicholas C
Publicado no Clin Cancer Res (2017)