Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations

BACKGROUND: Several thousand breast cancer patients develop resistance to aromatase inhibitors (AIs) each year in the UK. Rational treatment requires an improved molecular characterisation of resistant disease. MATERIALS AND METHODS: The mutational landscape of 198 regions in 16 key breast cancer ge...

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Vydáno v:Br J Cancer
Hlavní autoři: Lopez-Knowles, Elena, Pearson, Alex, Schuster, Gene, Gellert, Pascal, Ribas, Ricardo, Yeo, Belinda, Cutts, Ros, Buus, Richard, Garcia-Murillas, Isaac, Haynes, Ben, Martin, Lesley-Ann, Smith, Ian, Turner, Nick, Dowsett, Mitch
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342946/
https://ncbi.nlm.nih.gov/pubmed/30563991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0345-x
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