Genomic Instability and TP53 Genomic Alterations Associate With Poor Antiproliferative Response and Intrinsic Resistance to Aromatase Inhibitor Treatment

PURPOSE: Although aromatase inhibitor (AI) treatment is effective in estrogen receptor–positive postmenopausal breast cancer, resistance is common and incompletely explained. Genomic instability, as measured by somatic copy number alterations (SCNAs), is important in breast cancer development and pr...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Schuster, Eugene F., Gellert, Pascal, Segal, Corrinne V., López-Knowles, Elena, Buus, Richard, Cheang, Maggie Chon U., Morden, James, Robertson, John, Bliss, Judith M., Smith, Ian, Dowsett, Mitch
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446335/
https://ncbi.nlm.nih.gov/pubmed/32914010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00286
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