Genomic Instability and TP53 Genomic Alterations Associate With Poor Antiproliferative Response and Intrinsic Resistance to Aromatase Inhibitor Treatment

PURPOSE: Although aromatase inhibitor (AI) treatment is effective in estrogen receptor–positive postmenopausal breast cancer, resistance is common and incompletely explained. Genomic instability, as measured by somatic copy number alterations (SCNAs), is important in breast cancer development and pr...

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Dades bibliogràfiques
Publicat a:JCO Precis Oncol
Autors principals: Schuster, Eugene F., Gellert, Pascal, Segal, Corrinne V., López-Knowles, Elena, Buus, Richard, Cheang, Maggie Chon U., Morden, James, Robertson, John, Bliss, Judith M., Smith, Ian, Dowsett, Mitch
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2019
Matèries:
Original Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446335/
https://ncbi.nlm.nih.gov/pubmed/32914010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00286
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