Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Acquired ESR1 mutations are a major mechanism of resistance to aromatase inhibitors (AI). We developed ultra-high sensitivity multiplexed digital PCR assays for ESR1 mutations in circulating tumor DNA (ctDNA) and used these to investigate the clinical relevance and origin of ESR1 mutations in a coho...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Schiavon, Gaia, Hrebien, Sarah, Garcia-Murillas, Isaac, Cutts, Rosalind J, Pearson, Alex, Tarazona, Noelia, Fenwick, Kerry, Kozarewa, Iwanka, Lopez-Knowles, Elena, Ribas, Ricardo, Nerurkar, Ashutosh, Osin, Peter, Chandarlapaty, Sarat, Martin, Lesley-Ann, Dowsett, Mitch, Smith, Ian E, Turner, Nicholas C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998737/
https://ncbi.nlm.nih.gov/pubmed/26560360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac7551
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