Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

Por Chen, Dongsheng, Pace, Paul E., Coombes, R. Charles, Ali, Simak
Publicado em 1999

Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity

Por Thomas, Ross S, Sarwar, Naveed, Phoenix, Fladia, Coombes, R Charles, Ali, Simak
Publicado em 2008

Development of a Novel Molecular Sensor for Imaging Estrogen Receptor-Coactivator Protein-Protein Interactions

Por Lake, Madryn C., Nguyen, Quang-Dé, Ali, Simak, Aboagye, Eric O.
Publicado em 2012

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells

Por Ottaviani, Silvia, Brooke, Greg N, O'Hanlon-Brown, Ciara, Waxman, Jonathan, Ali, Simak, Buluwela, Laki
Publicado em 2013

Engineered repressors are potent inhibitors of androgen receptor activity

Por Brooke, Greg N., Powell, Sue M., Lavery, Derek N., Waxman, Jonathan, Buluwela, Laki, Ali, Simak, Bevan, Charlotte L.
Publicado em 2014

ERBB2 regulation by Estrogen Receptor-Pax2 determines tamoxifen response

Por Hurtado, Antoni, Holmes, Kelly A., Geistlinger, Timothy R., Hutcheson, Iain R., Nicholson, Robert I., Brown, Myles, Jiang, Jie, Howat, William J., Ali, Simak, Carroll, Jason S.
Publicado em 2008

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner

Por Kramer, Holly B., Lai, Chun-Fui, Patel, Hetal, Periyasamy, Manikandan, Lin, Meng-Lay, Feller, Stephan M., Fuller-Pace, Frances V., Meek, David W., Ali, Simak, Buluwela, Laki
Publicado no Nucleic Acids Res (2016)

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases

Por Lopez-Garcia, Jorge, Periyasamy, Manikandan, Thomas, Ross S., Christian, Mark, Leao, Maria, Jat, Parmjit, Kindle, Karin B., Heery, David M., Parker, Malcolm G., Buluwela, Lakjaya, Kamalati, Tahereh, Ali, Simak
Publicado em 2006

Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes

Por Mollet, Inês G., Patel, Dilipkumar, Govani, Fatima S., Giess, Adam, Paschalaki, Koralia, Periyasamy, Manikandan, Lidington, Elaine C., Mason, Justin C., Jones, Michael D., Game, Laurence, Ali, Simak, Shovlin, Claire L.
Publicado no PLoS One (2016)

A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk

Por Long, Jirong, Delahanty, Ryan J., Li, Guoliang, Gao, Yu-Tang, Lu, Wei, Cai, Qiuyin, Xiang, Yong-Bing, Li, Chun, Ji, Bu-Tian, Zheng, Ying, Ali, Simak, Shu, Xiao-Ou, Zheng, Wei
Publicado em 2013

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Por Ross-Innes, Caryn S., Stark, Rory, Teschendorff, Andrew E., Holmes, Kelly A., Ali, H. Raza, Dunning, Mark J., Brown, Gordon D., Gojis, Ondrej, Ellis, Ian O., Green, Andrew R., Ali, Simak, Chin, Suet-Feung, Palmieri, Carlo, Caldas, Carlos, Carroll, Jason S.
Publicado em 2012

T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif

Por Lucey, Marie J., Chen, Dongsheng, Lopez-Garcia, Jorge, Hart, Stephen M., Phoenix, Fladia, Al-Jehani, Rajai, Alao, John P., White, Roger, Kindle, Karin B., Losson, Régine, Chambon, Pierre, Parker, Malcolm G., Schär, Primo, Heery, David M., Buluwela, Lakjaya, Ali, Simak
Publicado em 2005

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells

Por Lai, Chun-Fui, Flach, Koen D., Alexi, Xanthippi, Fox, Stephen P., Ottaviani, Silvia, Thiruchelvam, Paul T.R., Kyle, Fiona J., Thomas, Ross S., Launchbury, Rosalind, Hua, Hui, Callaghan, Holly B., Carroll, Jason S., Charles Coombes, R., Zwart, Wilbert, Buluwela, Laki, Ali, Simak
Publicado em 2013

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Por Nguyen, Van T. M., Barozzi, Iros, Faronato, Monica, Lombardo, Ylenia, Steel, Jennifer H., Patel, Naina, Darbre, Philippa, Castellano, Leandro, Győrffy, Balázs, Woodley, Laura, Meira, Alba, Patten, Darren K., Vircillo, Valentina, Periyasamy, Manikandan, Ali, Simak, Frige, Gianmaria, Minucci, Saverio, Coombes, R. Charles, Magnani, Luca
Publicado no Nat Commun (2015)

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

Por Magnani, Luca, Frige, Gianmaria, Gadaleta, Raffaella Maria, Corleone, Giacomo, Fabris, Sonia, Kempe, Mannus H., Vershure, Pernette J., Barozzi, Iros, Vircillo, Valentina, Hong, Sung-Pil, Perone, Ylenia, Saini, Massimo, Trumpp, Andreas, Viale, Giuseppe, Neri, Antonino, Ali, Simak, Colleoni, Marco Angelo, Pruneri, Giancarlo, Minucci, Saverio
Publicado no Nat Genet (2017)

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations

Por Fulton, Joel, Mazumder, Bismoy, Whitchurch, Jonathan B, Monteiro, Cintia J, Collins, Hilary M, Chan, Chun M, Clemente, Maria P, Hernandez-Quiles, Miguel, Stewart, Elizabeth A, Amoaku, Winfried M, Moran, Paula M, Mongan, Nigel P, Persson, Jenny L, Ali, Simak, Heery, David M
Publicado no Cell Death Dis (2017)

The development of a selective cyclin-dependent kinase inhibitor which demonstrates anti-tumor activity

Por Ali, Simak, Heathcote, Dean A., Kroll, Sebastian H. B., Jogalekar, Ashutosh S., Scheiper, Bodo, Patel, Hetal, Brackow, Jan, Siwicka, Alekasandra, Fuchter, Matthew J., Periyasamy, Manikandan, Tolhurst, Robert S., Kanneganti, Seshu K., Snyder, James P., Liotta, Dennis C., Aboagye, Eric O., Barrett, Anthony G. M., Coombes, R. Charles
Publicado em 2009

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

Por Periyasamy, Manikandan, Patel, Hetal, Lai, Chun-Fui, Nguyen, Van T.M., Nevedomskaya, Ekaterina, Harrod, Alison, Russell, Roslin, Remenyi, Judit, Ochocka, Anna Maria, Thomas, Ross S., Fuller-Pace, Frances, Győrffy, Balázs, Caldas, Carlos, Navaratnam, Naveenan, Carroll, Jason S., Zwart, Wilbert, Coombes, R. Charles, Magnani, Luca, Buluwela, Laki, Ali, Simak
Publicado no Cell Rep (2015)

Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast Cancer

Por Patel, Hetal, Abduljabbar, Rezvan, Lai, Chun-Fui, Periyasamy, Manikandan, Harrod, Alison, Gemma, Carolina, Steel, Jennifer H., Patel, Naina, Busonero, Claudia, Jerjees, Dena, Remenyi, Judit, Smith, Sally, Gomm, Jennifer J., Magnani, Luca, Győrffy, Balázs, Jones, Louise J., Fuller-Pace, Frances, Shousha, Sami, Buluwela, Laki, Rakha, Emad A., Ellis, Ian O., Coombes, R. Charles, Ali, Simak
Publicado no Clin Cancer Res (2016)

Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer

Por Lin, Meng-Lay, Patel, Hetal, Remenyi, Judit, Banerji, Christopher R.S., Lai, Chun-Fui, Periyasamy, Manikandan, Lombardo, Ylenia, Busonero, Claudia, Ottaviani, Silvia, Passey, Alun, Quinlan, Philip R., Purdie, Colin A., Jordan, Lee B., Thompson, Alastair M., Finn, Richard S., Rueda, Oscar M., Caldas, Carlos, Gil, Jesus, Coombes, R. Charles, Fuller-Pace, Frances V., Teschendorff, Andrew E., Buluwela, Laki, Ali, Simak
Publicado no Oncotarget (2015)