Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

Small-molecule inhibitors of the CDK4/6 cell-cycle kinases have shown clinical efficacy in estrogen receptor (ER)-positive metastatic breast cancer, although their cytostatic effects are limited by primary and acquired resistance. Here we report that ER-positive breast cancer cells can adapt quickly...

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Pubblicato in:Cancer Res
Autori principali: Herrera-Abreu, Maria Teresa, Palafox, Marta, Asghar, Uzma, Rivas, Martín A., Cutts, Rosalind J., Garcia-Murillas, Isaac, Pearson, Alex, Guzman, Marta, Rodriguez, Olga, Grueso, Judit, Bellet, Meritxell, Cortés, Javier, Elliott, Richard, Pancholi, Sunil, Lord, Christopher J., Baselga, José, Dowsett, Mitch, Martin, Lesley-Ann, Turner, Nicholas C., Serra, Violeta
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426059/
https://ncbi.nlm.nih.gov/pubmed/27020857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0728
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