Loss of a Conserved Tyrosine Residue of Cytochrome b Induces Reactive Oxygen Species Production by Cytochrome bc(1)

von Lee, Dong-Woo, Selamoglu, Nur, Lanciano, Pascal, Cooley, Jason W., Forquer, Isaac, Kramer, David M., Daldal, Fevzi
Veröffentlicht 2011

Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs

von Soysa, Radika, Wilson, Zachary N., Elferich, Johannes, Forquer, Isaac, Shinde, Ujwal, Riscoe, Michael K., Yates, Phillip A., Ullman, Buddy
Veröffentlicht 2013

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

von Smilkstein, Martin J., Forquer, Isaac, Kanazawa, Atsuko, Kelly, Jane Xu, Winter, Rolf W., Hinrichs, David J., Kramer, David M., Riscoe, Michael K.
Veröffentlicht 2008

Targeting the Cytochrome bc(1) Complex of Leishmania Parasites for Discovery of Novel Drugs

von Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K., Ullman, Buddy, Landfear, Scott M.
Veröffentlicht in Antimicrob Agents Chemother (2016)

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

von Rozanov, Dmitri, Cheltsov, Anton, Nilsen, Aaron, Boniface, Christopher, Forquer, Isaac, Korkola, James, Gray, Joe, Tyner, Jeffrey, Tognon, Cristina E., Mills, Gordon B., Spellman, Paul
Veröffentlicht in PLoS One (2019)

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance

von Bannon, Amber E, Kent, Jason, Forquer, Isaac, Town, Ajia, Klug, Lillian R., McCann, Kelly, Beadling, Carol, Harismendy, Oliver, Sicklick, Jason K., Corless, Christopher, Shinde, Ujwal, Heinrich, Michael C.
Veröffentlicht in Clin Cancer Res (2017)

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc(1) Inhibition Strategy for Malaria

von Stickles, Allison M., Smilkstein, Martin J., Morrisey, Joanne M., Li, Yuexin, Forquer, Isaac P., Kelly, Jane X., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Vaidya, Akhil B., Riscoe, Michael K.
Veröffentlicht in Antimicrob Agents Chemother (2016)

Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc(1) Complex of Plasmodium falciparum

von Stickles, Allison M., de Almeida, Mariana Justino, Morrisey, Joanne M., Sheridan, Kayla A., Forquer, Isaac P., Nilsen, Aaron, Winter, Rolf W., Burrows, Jeremy N., Fidock, David A., Vaidya, Akhil B., Riscoe, Michael K.
Veröffentlicht in Antimicrob Agents Chemother (2015)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

von Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W., Jones-Brando, Lorraine, Yolken, Robert H., Bordón, Claudia, Charman, Susan A., Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N., Hinrichs, David J., Meunier, Brigitte, Carruthers, Vern B., Riscoe, Michael K.
Veröffentlicht 2012

Inhibition of Cytochrome bc(1) as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

von Stickles, Allison M., Ting, Li-Min, Morrisey, Joanne M., Li, Yuexin, Mather, Michael W., Meermeier, Erin, Pershing, April M., Forquer, Isaac P., Miley, Galen P., Pou, Sovitj, Winter, Rolf W., Hinrichs, David J., Kelly, Jane X., Kim, Kami, Vaidya, Akhil B., Riscoe, Michael K., Nilsen, Aaron
Veröffentlicht in Am J Trop Med Hyg (2015)

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

von Frueh, Lisa, LI, Yuexin, Mather, Michael W., Li, Qigui, Pou, Sovitj, Nilsen, Aaron, Winter, Rolf W., Forquer, Isaac P., Pershing, April M., Xie, Lisa H., Smilkstein, Martin J., Caridha, Diana, Campbell, Robert F., Sciotti, Richard J., Kreishman-Deitrick, Mara, Kelly, Jane X., Vesely, Brian, Vaidya, Akhil B., Riscoe, Michael K
Veröffentlicht in ACS Infect Dis (2017)

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

von Nilsen, Aaron, Miley, Galen P., Forquer, Isaac P., Mather, Michael W., Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M., Stickles, Allison M., Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L., Hinrichs, David J., Winter, Rolf W., Charman, Susan A., Zakharov, Lev N., Bathurst, Ian, Burrows, Jeremy N., Vaidya, Akhil B., Riscoe, Michael K.
Veröffentlicht 2014

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

von Miley, Galen P., Pou, Sovitj, Winter, Rolf, Nilsen, Aaron, Li, Yuexin, Kelly, Jane X., Stickles, Allison M., Mather, Michael W., Forquer, Isaac P., Pershing, April M., White, Karen, Shackleford, David, Saunders, Jessica, Chen, Gong, Ting, Li-Min, Kim, Kami, Zakharov, Lev N., Donini, Cristina, Burrows, Jeremy N., Vaidya, Akhil B., Charman, Susan A., Riscoe, Michael K.
Veröffentlicht in Antimicrob Agents Chemother (2015)

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

von Lawres, Lauren A., Garg, Aprajita, Kumar, Vidya, Bruzual, Igor, Forquer, Isaac P., Renard, Isaline, Virji, Azan Z., Boulard, Pierre, Rodriguez, Eduardo X., Allen, Alexander J., Pou, Sovitj, Wegmann, Keith W., Winter, Rolf W., Nilsen, Aaron, Mao, Jialing, Preston, Douglas A., Belperron, Alexia A., Bockenstedt, Linda K., Hinrichs, David J., Riscoe, Michael K., Doggett, J. Stone, Ben Mamoun, Choukri
Veröffentlicht in J Exp Med (2016)

Chemical genetics of Plasmodium falciparum

von Guiguemde, W. Armand, Shelat, Anang A., Bouck, David, Duffy, Sandra, Crowther, Gregory J., Davis, Paul H., Smithson, David C., Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B., Tripathi, Abhai K., Gut, Jiri, Sharlow, Elizabeth R., Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J., DeRisi, Joseph L, Sullivan, David J., Lazo, John S., Roos, David S., Riscoe, Michael K., Phillips, Margaret A., Rathod, Pradipsinh K., Van Voorhis, Wesley C., Avery, Vicky M, Guy, R. Kiplin
Veröffentlicht 2010

Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

von Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
Veröffentlicht in Sci Transl Med (2013)