Loss of a Conserved Tyrosine Residue of Cytochrome b Induces Reactive Oxygen Species Production by Cytochrome bc(1)

অনুযায়ী Lee, Dong-Woo, Selamoglu, Nur, Lanciano, Pascal, Cooley, Jason W., Forquer, Isaac, Kramer, David M., Daldal, Fevzi
প্রকাশিত 2011

Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs

অনুযায়ী Soysa, Radika, Wilson, Zachary N., Elferich, Johannes, Forquer, Isaac, Shinde, Ujwal, Riscoe, Michael K., Yates, Phillip A., Ullman, Buddy
প্রকাশিত 2013

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

অনুযায়ী Smilkstein, Martin J., Forquer, Isaac, Kanazawa, Atsuko, Kelly, Jane Xu, Winter, Rolf W., Hinrichs, David J., Kramer, David M., Riscoe, Michael K.
প্রকাশিত 2008

Targeting the Cytochrome bc(1) Complex of Leishmania Parasites for Discovery of Novel Drugs

অনুযায়ী Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K., Ullman, Buddy, Landfear, Scott M.
প্রকাশিত Antimicrob Agents Chemother (2016)

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

অনুযায়ী Rozanov, Dmitri, Cheltsov, Anton, Nilsen, Aaron, Boniface, Christopher, Forquer, Isaac, Korkola, James, Gray, Joe, Tyner, Jeffrey, Tognon, Cristina E., Mills, Gordon B., Spellman, Paul
প্রকাশিত PLoS One (2019)

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance

অনুযায়ী Bannon, Amber E, Kent, Jason, Forquer, Isaac, Town, Ajia, Klug, Lillian R., McCann, Kelly, Beadling, Carol, Harismendy, Oliver, Sicklick, Jason K., Corless, Christopher, Shinde, Ujwal, Heinrich, Michael C.
প্রকাশিত Clin Cancer Res (2017)

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc(1) Inhibition Strategy for Malaria

অনুযায়ী Stickles, Allison M., Smilkstein, Martin J., Morrisey, Joanne M., Li, Yuexin, Forquer, Isaac P., Kelly, Jane X., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Vaidya, Akhil B., Riscoe, Michael K.
প্রকাশিত Antimicrob Agents Chemother (2016)

Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc(1) Complex of Plasmodium falciparum

অনুযায়ী Stickles, Allison M., de Almeida, Mariana Justino, Morrisey, Joanne M., Sheridan, Kayla A., Forquer, Isaac P., Nilsen, Aaron, Winter, Rolf W., Burrows, Jeremy N., Fidock, David A., Vaidya, Akhil B., Riscoe, Michael K.
প্রকাশিত Antimicrob Agents Chemother (2015)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

অনুযায়ী Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W., Jones-Brando, Lorraine, Yolken, Robert H., Bordón, Claudia, Charman, Susan A., Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N., Hinrichs, David J., Meunier, Brigitte, Carruthers, Vern B., Riscoe, Michael K.
প্রকাশিত 2012

Inhibition of Cytochrome bc(1) as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

অনুযায়ী Stickles, Allison M., Ting, Li-Min, Morrisey, Joanne M., Li, Yuexin, Mather, Michael W., Meermeier, Erin, Pershing, April M., Forquer, Isaac P., Miley, Galen P., Pou, Sovitj, Winter, Rolf W., Hinrichs, David J., Kelly, Jane X., Kim, Kami, Vaidya, Akhil B., Riscoe, Michael K., Nilsen, Aaron
প্রকাশিত Am J Trop Med Hyg (2015)

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

অনুযায়ী Frueh, Lisa, LI, Yuexin, Mather, Michael W., Li, Qigui, Pou, Sovitj, Nilsen, Aaron, Winter, Rolf W., Forquer, Isaac P., Pershing, April M., Xie, Lisa H., Smilkstein, Martin J., Caridha, Diana, Campbell, Robert F., Sciotti, Richard J., Kreishman-Deitrick, Mara, Kelly, Jane X., Vesely, Brian, Vaidya, Akhil B., Riscoe, Michael K
প্রকাশিত ACS Infect Dis (2017)

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

অনুযায়ী Nilsen, Aaron, Miley, Galen P., Forquer, Isaac P., Mather, Michael W., Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M., Stickles, Allison M., Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L., Hinrichs, David J., Winter, Rolf W., Charman, Susan A., Zakharov, Lev N., Bathurst, Ian, Burrows, Jeremy N., Vaidya, Akhil B., Riscoe, Michael K.
প্রকাশিত 2014

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

অনুযায়ী Miley, Galen P., Pou, Sovitj, Winter, Rolf, Nilsen, Aaron, Li, Yuexin, Kelly, Jane X., Stickles, Allison M., Mather, Michael W., Forquer, Isaac P., Pershing, April M., White, Karen, Shackleford, David, Saunders, Jessica, Chen, Gong, Ting, Li-Min, Kim, Kami, Zakharov, Lev N., Donini, Cristina, Burrows, Jeremy N., Vaidya, Akhil B., Charman, Susan A., Riscoe, Michael K.
প্রকাশিত Antimicrob Agents Chemother (2015)

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

অনুযায়ী Lawres, Lauren A., Garg, Aprajita, Kumar, Vidya, Bruzual, Igor, Forquer, Isaac P., Renard, Isaline, Virji, Azan Z., Boulard, Pierre, Rodriguez, Eduardo X., Allen, Alexander J., Pou, Sovitj, Wegmann, Keith W., Winter, Rolf W., Nilsen, Aaron, Mao, Jialing, Preston, Douglas A., Belperron, Alexia A., Bockenstedt, Linda K., Hinrichs, David J., Riscoe, Michael K., Doggett, J. Stone, Ben Mamoun, Choukri
প্রকাশিত J Exp Med (2016)

Chemical genetics of Plasmodium falciparum

অনুযায়ী Guiguemde, W. Armand, Shelat, Anang A., Bouck, David, Duffy, Sandra, Crowther, Gregory J., Davis, Paul H., Smithson, David C., Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B., Tripathi, Abhai K., Gut, Jiri, Sharlow, Elizabeth R., Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J., DeRisi, Joseph L, Sullivan, David J., Lazo, John S., Roos, David S., Riscoe, Michael K., Phillips, Margaret A., Rathod, Pradipsinh K., Van Voorhis, Wesley C., Avery, Vicky M, Guy, R. Kiplin
প্রকাশিত 2010

Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

অনুযায়ী Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
প্রকাশিত Sci Transl Med (2013)