Loss of a Conserved Tyrosine Residue of Cytochrome b Induces Reactive Oxygen Species Production by Cytochrome bc(1)

מאת Lee, Dong-Woo, Selamoglu, Nur, Lanciano, Pascal, Cooley, Jason W., Forquer, Isaac, Kramer, David M., Daldal, Fevzi
יצא לאור 2011

Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs

מאת Soysa, Radika, Wilson, Zachary N., Elferich, Johannes, Forquer, Isaac, Shinde, Ujwal, Riscoe, Michael K., Yates, Phillip A., Ullman, Buddy
יצא לאור 2013

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

מאת Smilkstein, Martin J., Forquer, Isaac, Kanazawa, Atsuko, Kelly, Jane Xu, Winter, Rolf W., Hinrichs, David J., Kramer, David M., Riscoe, Michael K.
יצא לאור 2008

Targeting the Cytochrome bc(1) Complex of Leishmania Parasites for Discovery of Novel Drugs

מאת Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K., Ullman, Buddy, Landfear, Scott M.
הוצא לאור ב Antimicrob Agents Chemother (2016)

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

מאת Rozanov, Dmitri, Cheltsov, Anton, Nilsen, Aaron, Boniface, Christopher, Forquer, Isaac, Korkola, James, Gray, Joe, Tyner, Jeffrey, Tognon, Cristina E., Mills, Gordon B., Spellman, Paul
הוצא לאור ב PLoS One (2019)

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance

מאת Bannon, Amber E, Kent, Jason, Forquer, Isaac, Town, Ajia, Klug, Lillian R., McCann, Kelly, Beadling, Carol, Harismendy, Oliver, Sicklick, Jason K., Corless, Christopher, Shinde, Ujwal, Heinrich, Michael C.
הוצא לאור ב Clin Cancer Res (2017)

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc(1) Inhibition Strategy for Malaria

מאת Stickles, Allison M., Smilkstein, Martin J., Morrisey, Joanne M., Li, Yuexin, Forquer, Isaac P., Kelly, Jane X., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Vaidya, Akhil B., Riscoe, Michael K.
הוצא לאור ב Antimicrob Agents Chemother (2016)

Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc(1) Complex of Plasmodium falciparum

מאת Stickles, Allison M., de Almeida, Mariana Justino, Morrisey, Joanne M., Sheridan, Kayla A., Forquer, Isaac P., Nilsen, Aaron, Winter, Rolf W., Burrows, Jeremy N., Fidock, David A., Vaidya, Akhil B., Riscoe, Michael K.
הוצא לאור ב Antimicrob Agents Chemother (2015)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

מאת Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W., Jones-Brando, Lorraine, Yolken, Robert H., Bordón, Claudia, Charman, Susan A., Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N., Hinrichs, David J., Meunier, Brigitte, Carruthers, Vern B., Riscoe, Michael K.
יצא לאור 2012

Inhibition of Cytochrome bc(1) as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

מאת Stickles, Allison M., Ting, Li-Min, Morrisey, Joanne M., Li, Yuexin, Mather, Michael W., Meermeier, Erin, Pershing, April M., Forquer, Isaac P., Miley, Galen P., Pou, Sovitj, Winter, Rolf W., Hinrichs, David J., Kelly, Jane X., Kim, Kami, Vaidya, Akhil B., Riscoe, Michael K., Nilsen, Aaron
הוצא לאור ב Am J Trop Med Hyg (2015)

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

מאת Frueh, Lisa, LI, Yuexin, Mather, Michael W., Li, Qigui, Pou, Sovitj, Nilsen, Aaron, Winter, Rolf W., Forquer, Isaac P., Pershing, April M., Xie, Lisa H., Smilkstein, Martin J., Caridha, Diana, Campbell, Robert F., Sciotti, Richard J., Kreishman-Deitrick, Mara, Kelly, Jane X., Vesely, Brian, Vaidya, Akhil B., Riscoe, Michael K
הוצא לאור ב ACS Infect Dis (2017)

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

מאת Nilsen, Aaron, Miley, Galen P., Forquer, Isaac P., Mather, Michael W., Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M., Stickles, Allison M., Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L., Hinrichs, David J., Winter, Rolf W., Charman, Susan A., Zakharov, Lev N., Bathurst, Ian, Burrows, Jeremy N., Vaidya, Akhil B., Riscoe, Michael K.
יצא לאור 2014

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

מאת Miley, Galen P., Pou, Sovitj, Winter, Rolf, Nilsen, Aaron, Li, Yuexin, Kelly, Jane X., Stickles, Allison M., Mather, Michael W., Forquer, Isaac P., Pershing, April M., White, Karen, Shackleford, David, Saunders, Jessica, Chen, Gong, Ting, Li-Min, Kim, Kami, Zakharov, Lev N., Donini, Cristina, Burrows, Jeremy N., Vaidya, Akhil B., Charman, Susan A., Riscoe, Michael K.
הוצא לאור ב Antimicrob Agents Chemother (2015)

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

מאת Lawres, Lauren A., Garg, Aprajita, Kumar, Vidya, Bruzual, Igor, Forquer, Isaac P., Renard, Isaline, Virji, Azan Z., Boulard, Pierre, Rodriguez, Eduardo X., Allen, Alexander J., Pou, Sovitj, Wegmann, Keith W., Winter, Rolf W., Nilsen, Aaron, Mao, Jialing, Preston, Douglas A., Belperron, Alexia A., Bockenstedt, Linda K., Hinrichs, David J., Riscoe, Michael K., Doggett, J. Stone, Ben Mamoun, Choukri
הוצא לאור ב J Exp Med (2016)

Chemical genetics of Plasmodium falciparum

מאת Guiguemde, W. Armand, Shelat, Anang A., Bouck, David, Duffy, Sandra, Crowther, Gregory J., Davis, Paul H., Smithson, David C., Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B., Tripathi, Abhai K., Gut, Jiri, Sharlow, Elizabeth R., Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J., DeRisi, Joseph L, Sullivan, David J., Lazo, John S., Roos, David S., Riscoe, Michael K., Phillips, Margaret A., Rathod, Pradipsinh K., Van Voorhis, Wesley C., Avery, Vicky M, Guy, R. Kiplin
יצא לאור 2010

Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

מאת Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
הוצא לאור ב Sci Transl Med (2013)