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Targeting the Cytochrome bc(1) Complex of Leishmania Parasites for Discovery of Novel Drugs

Endochin-like quinolones (ELQs) are potent and specific inhibitors of cytochrome bc(1) from Plasmodium falciparum and Toxoplasma gondii and show promise for novel antiparasitic drug development. To determine whether the mitochondrial electron transport chain of Leishmania parasites could be targeted...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K., Ullman, Buddy, Landfear, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958202/
https://ncbi.nlm.nih.gov/pubmed/27297476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00850-16
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