Chemical genetics of Plasmodium falciparum

Malaria caused by Plasmodium falciparum is a catastrophic disease worldwide (880,000 deaths yearly). Vaccine development has proved difficult and resistance has emerged for most antimalarials. In order to discover new antimalarial chemotypes, we have employed a phenotypic forward chemical genetic ap...

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Detalhes bibliográficos
Main Authors: Guiguemde, W. Armand, Shelat, Anang A., Bouck, David, Duffy, Sandra, Crowther, Gregory J., Davis, Paul H., Smithson, David C., Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B., Tripathi, Abhai K., Gut, Jiri, Sharlow, Elizabeth R., Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J., DeRisi, Joseph L, Sullivan, David J., Lazo, John S., Roos, David S., Riscoe, Michael K., Phillips, Margaret A., Rathod, Pradipsinh K., Van Voorhis, Wesley C., Avery, Vicky M, Guy, R. Kiplin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874979/
https://ncbi.nlm.nih.gov/pubmed/20485428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09099
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