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Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase

Human African trypanosomiasis, caused by the eukaryotic parasite Trypanosoma brucei, is a serious health problem in much of central Africa. The only validated molecular target for treatment of human African trypanosomiasis is ornithine decarboxylase (ODC), which catalyzes the first step in polyamine...

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Bibliografische gegevens
Hoofdauteurs: Smithson, David C., Lee, Jeongmi, Shelat, Anang A., Phillips, Margaret A., Guy, R. Kiplin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878083/
https://ncbi.nlm.nih.gov/pubmed/20220141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081588
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